Endocrine Abstracts

In recent years there has been considerable progress in identifying how insulin signals to the cell's interior. The interaction of insulin with its receptor triggers the formation of phosphatidyl inositol (3, 4, 5) trisphosphate (PIP3) at the plasma membrane which then activates several signal transduction pathways. Perhaps the most important of these is the protein kinase cascade in which 3-phosphoinositide-dependent protein kinase-1 (PDK1) activates protein kinase B (PKB, al...